Conserved antigenic sites between MERS-CoV and Bat-coronavirus are revealed through sequence analysis
Identifieur interne : 000F94 ( Main/Exploration ); précédent : 000F93; suivant : 000F95Conserved antigenic sites between MERS-CoV and Bat-coronavirus are revealed through sequence analysis
Auteurs : Refat Sharmin ; Abul B. M. M. K. Islam [Bangladesh]Source :
- Source Code for Biology and Medicine [ 1751-0473 ] ; 2016.
Abstract
MERS-CoV is a newly emerged human coronavirus reported closely related with HKU4 and HKU5 Bat coronaviruses. Bat and MERS corona-viruses are structurally related. Therefore, it is of interest to estimate the degree of conserved antigenic sites among them. It is of importance to elucidate the shared antigenic-sites and extent of conservation between them to understand the evolutionary dynamics of MERS-CoV.
Multiple sequence alignment of the spike (S), membrane (M), enveloped (E) and nucleocapsid (N) proteins was employed to identify the sequence conservation among MERS and Bat (HKU4, HKU5) coronaviruses. We used various
This sharing suggests that in case of pathogenicity MERS-CoV is more closely related to HKU5 bat-CoV than HKU4 bat-CoV. The conserved epitopes indicates their evolutionary relationship and ancestry of pathogenicity.
The online version of this article (doi:10.1186/s13029-016-0049-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13029-016-0049-7
PubMed: 26962326
PubMed Central: 4784407
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Conserved antigenic sites between MERS-CoV and Bat-coronavirus are revealed through sequence analysis</title><author><name sortKey="Sharmin, Refat" sort="Sharmin, Refat" uniqKey="Sharmin R" first="Refat" last="Sharmin">Refat Sharmin</name><affiliation><nlm:aff id="Aff1">Research and Development Department, Incepta Vaccine Ltd., Zirabo, Savar, Dhaka 1341 Bangladesh</nlm:aff><wicri:noCountry code="subfield">Dhaka 1341 Bangladesh</wicri:noCountry></affiliation></author><author><name sortKey="Islam, Abul B M M K" sort="Islam, Abul B M M K" uniqKey="Islam A" first="Abul B. M. M. K." last="Islam">Abul B. M. M. K. Islam</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Genetic Engineering and Biotechnology, University of Dhaka, Science Complex Building, Dhaka, 1000 Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Genetic Engineering and Biotechnology, University of Dhaka, Science Complex Building, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26962326</idno><idno type="pmc">4784407</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784407</idno><idno type="RBID">PMC:4784407</idno><idno type="doi">10.1186/s13029-016-0049-7</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000338</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000338</idno><idno type="wicri:Area/Pmc/Curation">000338</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000338</idno><idno type="wicri:Area/Pmc/Checkpoint">000493</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000493</idno><idno type="wicri:Area/Ncbi/Merge">000597</idno><idno type="wicri:Area/Ncbi/Curation">000597</idno><idno type="wicri:Area/Ncbi/Checkpoint">000597</idno><idno type="wicri:Area/Main/Merge">000F96</idno><idno type="wicri:Area/Main/Curation">000F94</idno><idno type="wicri:Area/Main/Exploration">000F94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Conserved antigenic sites between MERS-CoV and Bat-coronavirus are revealed through sequence analysis</title><author><name sortKey="Sharmin, Refat" sort="Sharmin, Refat" uniqKey="Sharmin R" first="Refat" last="Sharmin">Refat Sharmin</name><affiliation><nlm:aff id="Aff1">Research and Development Department, Incepta Vaccine Ltd., Zirabo, Savar, Dhaka 1341 Bangladesh</nlm:aff><wicri:noCountry code="subfield">Dhaka 1341 Bangladesh</wicri:noCountry></affiliation></author><author><name sortKey="Islam, Abul B M M K" sort="Islam, Abul B M M K" uniqKey="Islam A" first="Abul B. M. M. K." last="Islam">Abul B. M. M. K. Islam</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Genetic Engineering and Biotechnology, University of Dhaka, Science Complex Building, Dhaka, 1000 Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Genetic Engineering and Biotechnology, University of Dhaka, Science Complex Building, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author></analytic><series><title level="j">Source Code for Biology and Medicine</title><idno type="eISSN">1751-0473</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>MERS-CoV is a newly emerged human coronavirus reported closely related with HKU4 and HKU5 Bat coronaviruses. Bat and MERS corona-viruses are structurally related. Therefore, it is of interest to estimate the degree of conserved antigenic sites among them. It is of importance to elucidate the shared antigenic-sites and extent of conservation between them to understand the evolutionary dynamics of MERS-CoV.</p></sec><sec><title>Results</title><p>Multiple sequence alignment of the spike (S), membrane (M), enveloped (E) and nucleocapsid (N) proteins was employed to identify the sequence conservation among MERS and Bat (HKU4, HKU5) coronaviruses. We used various <italic>in silico</italic> tools to predict the conserved antigenic sites. We found that MERS-CoV shared 30 % of its S protein antigenic sites with HKU4 and 70 % with HKU5 bat-CoV. Whereas 100 % of its E, M and N protein’s antigenic sites are found to be conserved with those in HKU4 and HKU5.</p></sec><sec><title>Conclusion</title><p>This sharing suggests that in case of pathogenicity MERS-CoV is more closely related to HKU5 bat-CoV than HKU4 bat-CoV. The conserved epitopes indicates their evolutionary relationship and ancestry of pathogenicity.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13029-016-0049-7) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sharmin, R" uniqKey="Sharmin R">R Sharmin</name></author><author><name sortKey="Islam, Ab" uniqKey="Islam A">AB Islam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huynh, J" uniqKey="Huynh J">J 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